Modulating autophagy to treat CV disease

Brought to you by the Fondation Leducq Transatlantic Network of Excellence

Cuervo Lab

Tekirdag K, Cuervo AM. Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone. J Biol Chem. 2018 Apr 13;293(15):5414-5424. doi: 10.1074/jbc.R117.818237. Epub 2017 Dec 15. Review. PubMed PMID: 29247007; PubMed Central PMCID: PMC5900761.  

Gong Z, Tasset I, Diaz A, Anguiano J, Tas E, Cui L, Kuliawat R, Liu H, Kühn B, Cuervo AM, Muzumdar R. Humanin is an endogenous activator of chaperone-mediated autophagy. J Cell Biol. 2018 Feb 5;217(2):635-647. doi: 10.1083/jcb.201606095. Epub 2017 Nov 29. PubMed PMID: 29187525; PubMed Central PMCID: PMC5800795.  

Esteban-Martínez L, Sierra-Filardi E, McGreal RS, Salazar-Roa M, Mariño G, Seco E, Durand S, Enot D, Graña O, Malumbres M, Cvekl A, Cuervo AM, Kroemer G, Boya P. Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J. 2017 Jun 14;36(12):1688-1706. doi: 10.15252/embj.201695916. Epub 2017 May 2. PubMed PMID: 28465321; PubMed Central PMCID: PMC5470043.  

Madrigal-Matute J, Cuervo AM. Regulation of Liver Metabolism by Autophagy.Gastroenterology. 2016 Feb;150(2):328-39. doi: 10.1053/j.gastro.2015.09.042.Review. PubMed PMID: 26453774; PubMed Central PMCID: PMC4728051.

Kaushik S, Cuervo AM. Proteostasis and aging. Nat Med. 2015Dec;21(12):1406-15. doi: 10.1038/nm.4001. Review. PubMed PMID: 26646497.

Kaushik S, Cuervo AM. AMPK-dependent phosphorylation of lipid droplet proteinPLIN2 triggers its degradation by CMA. Autophagy. 2016;12(2):432-8. doi:10.1080/15548627.2015.1124226. PubMed PMID: 26902588; PubMed Central PMCID:PMC4835968

Tasset I, Cuervo AM. Role of chaperone-mediated autophagy in metabolism. FEBS J. 2016 Jul;283(13):2403-13. doi: 10.1111/febs.13677. Review. PubMed PMID:26854402; PubMed Central PMCID: PMC4935551.

 

KITSIS LAB

Riascos-Bernal DF, Sibinga NES , Kitsis RN. PDCD5 says no to NO. Proc Natl AcadSci U S A. 2018 May 1;115(18):4535-4537. doi: 10.1073/pnas.1804491115. Epub 2018Apr 16. PubMed PMID: 29666279.

Shires SE,  Kitsis RN, Gustafsson ÅB. Beyond Mitophagy: The Diversity andCom  plexity of Parkin Function. Circ Res. 2017 Apr 14;120(8):1234-1236. doi:10.1161/CIRCRESAHA.116.310179. PubMed PMID: 28408450; PubMed Central PMCID:PMC5407365.

Amgalan D, Pekson R, Kitsis RN. Troponin release  following brief  myocardiali schemia: apoptosis versus necrosis. JACC Basic Transl Sci. 2017Apr;2(2):118-121. doi: 10.1016/j.jacbts.2017.03.008. Epub 2017 Apr 24. PubMedPMID: 29034357; PubMed Central PMCID: PMC5637406.

McKimpson WM, Kitsis RN. A New Role for the ER Unfolded Protein Response Mediator  ATF6: Induction of a Generalized Antioxidant Program. Circ Res. 2017 Mar3;120(5):759-761. doi: 10.1161/CIRCRESAHA.117.310577. PubMed PMID: 28254796; PubMed Central PMCID: PMC5345692.

Linkermann A, Konstantinidis K, Kitsis RN. Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction. Cell Death Differ, 2016. 23:1-2.

Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson AB, Kitsis RN, Sadoshima J. Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol, 2016. 92:134-139.

Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn II GW, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ. Mitochondrial function, biology, and role in disease: a statement from the American Heart Association. Circ Res, 2016. 118:1960-1991.

Mera P, Laue K, Ferron M, Confavreux C, Wei J, Galan-Diez M, Lacampagne A, Mitchell SJ, Mattison JA, Chen Y, Bacchetta J, Szulc P, Kitsis RN, de Cabo R, Friedman RA, Torsitano C, McGraw TE, Puchowicz M, Kurland I, Karsenty G. Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise. Cell Metab, 2016. 23:1078-1092.

Nah J, Fernandez AF, Kitsis RN, Levine B, Sadoshima J. Does autophagy mediate cardiac myocyte death during stress? Circ Res, 2016. 119:893-895.

Franco A*, Kitsis RN*, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn 2nd GW. Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature, 2016. 540: 74-79. * equal contributions.

Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzales ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn II GW, Sadoshima J, Ellisman MH, Gustafsson AB. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun, 2017. 8:14050.

Stanley RF, Piszczatowski RT, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari S, Walter D, Todorova TI, Hirsch C, Makishima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, Steidl U. A myeloid tumor suppressor role for NOL3. J Exp Med, 2017. 214:753-771.

McKimpson WM, Kitsis RN. A new role for the ER unfolded protein response mediator ATF6: induction of a generalized antioxidant program. Circ Res, 2017. 120:759-761.

Shires SE, Kitsis RN, Gustafsson AB. Beyond mitophagy: The diversity and complexity of Parkin function. Circ Res, 2017. 120:1234-1236.

Amgalan D, Pekson R, Kitsis RN. Troponin release following brief myocardial ischemia: apoptosis versus necrosis. JACC: Basic to Translational Science, 2017. 2:118-121.

Moslehi J, Amgalan D, Kitsis RN. Grounding cardio-oncology in basic and clinical science. Circulation, 2017. 136:3-5.

McKimpson WM, Zheng M, Chua Jr SC, Pessin JE, Kitsis RN. ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes. Scientific Reports, 2017. 7:7019.

Yanamandala M, Zhu W, Garry DJ, Kamp T, Hare J, Jun H, Yoon YS, Bursac N, Prabhu S, Dorn II, GW, Bolli R, Kitsis RN, Zhang J. Overcoming the roadblocks to cardiac cell therapy using tissue engineering. J Am Coll Cardiol, 2017. 70:766-775.

Templin AT, Samarasekera T, Meier DT, Hogan MF, Mellati M, Crow MT, Kitsis RN, Zraika S, Hull RL, Kahn SE. Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced β-cell apoptosis and JNK pathway activation. Diabetes, 2017 (in press).

Amgalan D, Chen Y, Kitsis RN. Death receptor signaling in the heart: cell survival, apoptosis, necroptosis. Circulation, 2017 (in press).

Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Zhuang Z, Sharp DJ, Sibinga NE, Frangogiannis NG, Kitsis RN, Stanley P, Zhou B. Uncontrolled fetal coronary tip cells cause adult ischemic heart disease. Nat Commun, 2017 (in press).

Yao J, Loudig O, Suyama K, Chung S, McKimpson WM, Bajaj S, Wang Y, Phillips GR, Segall J, Norton L, Kitsis RN, Hazan RB. A paradoxical role for an Akt3 isoform in promoting apoptosis leading to suppression of mammary tumorigenesis. Cancer Res, 2017 (in press).

 

Levine lab

Sun Y, Yao X, Zhang Q-J, Zhu M, Liu Z-P, Carlson D, Rothermel BA, Sun Y, Levine B, Hill JA, Wolf SE, Minei JP and Zang QS. Beclin-1-dependent autophagy protects the heart during sepsis. Circulation; in revision.

Fernández AF, Sebti S, Wei Y, Zou Z, Shi, M, McMillan KL, He C, Chiang WC, Ting T, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, and Levine B. Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice. Nature; in press.

 

kroemer lab

Soussi T, Kroemer G. TP53 and 53BP1 Reunited. Trends Cell Biol. 2016 Nov 17. pii: S0962- 8924(16)30175-1. doi: 10.1016/j.tcb.2016.10.004. [Epub ahead of print]

Galluzzi L, Bravo-San Pedro JM, Demaria S, Formenti SC, Kroemer G. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol. 2016 Nov 15. doi: 10.1038/nrclinonc.2016.183. [Epub ahead of print]

Senovilla L, Demont Y, Humeau J, Bloy N, Kroemer G. Image Cytofluorometry for the Quantification of Ploidy and Endoplasmic Reticulum Stress in Cancer Cells. Methods Mol Biol. 2017;1524:53-64.

Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2016 Oct 17. In press Kroemer G Kepp O, Kroemer G. Necroptosis: mechanisms and relevance to disease. Annual Review of Pathology: Mechanisms of Disease. In press

Galluzzi L, Bravo San Pedo JM, Kroemer G. Autophagy research: new methods for an ancient process. Meth Enzymol in press Sica V, Izzo V, Bravo-San Pedro JM, Pietrocola F, Maiuri MC, Kroemer G, Galluzzi L. Assessment of glycolytic flux and mitochondrial respiration in the course of autophagic responses. Meth Enzymol in press

Bravo-San Pedro JM, Pietrocola F, Siva V, Izzo V, Maiuri MC, Kroemer G, Galluzzi L. High-throughput quantification of GFP-LC3 dots by automated fluorescence microscopy. Meth Enzymol in press

Sauvat A, Zhou H, Leduc M, Gomes-da-Silva LC, Besu L, Müller K, Forveille S, Liu P, Zhao L, Kroemer G*, Kepp O. (*Corresponding author). Automated analysis of fluorescence co-localization- Application to mitophagy. Meth Enzymol in press

Mondragon L, Kroemer G, Galluzzi L. Immunosuppressive γδ T cells foster pancreatic carcinogenesis. OncoImmunology in press

Fend L, Rusakievicz S, Adam J, Bastien B, Caignard A, Messaouden M, Iribarren C, Cremer I, Marabell A, Borg C, Semeraro M, Barraud L, Limahcher JM, Eggermont A, Kroemer G*, and Zitvogel L (*Corresponding author). Prognostic impact of the expression of NK cell receptors and PD-L1 on nonsmall cell lung cancer. OncoImmunology in press

Pietrocola F, Bravo San Pedro JM, Galluzzi L, Kroemer G. Autophagy in natural and therapy-driven anticancer immunosurveillance. Autophagy In press

Pietrocola F, Demont Y, Castoldi F, Enot D, Durand S, Semeraro M, Baracco EE, Pol J, Bravo San-Pedro JM, Bordenave C, Levesque S, Humeau J, Chery A, Metivier D, Madeo F, Maiuri P, Kroemer G. Metabolic effects of starvation on human and mouse leukocytes. Autophagy. In press

Izzo V, Pietrocola F, Sica V, Zhang S, Durand S, Lachkar S, Enot D, Bravo San Pedro JM, Chery A, Espositio S, Zamzami N, Raia V, Maiuri L, Maiuri MC, Kroemer G. Metabolic interactions between cysteamine and epigallocatechin gallate. Cell Cycle in press

Ferrari E, Monzani R, Vilella VR, Esposito S, Saluzzo F, Rossin F, D’Eletto M, Tosco A, De Gregorio F, Maiuri MC, Kroemer G*. Raia V, Maiuri L (*Corresponding author). Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del- CFTR mutation. Cell Death Dis. In press

Galluzzi L, Kroemer G. Secondary necrosis. Accidental no more. Trends Cancer. In press

Galluzzi L, Bravo San Pedro JM, Kroemer G. Prohibitin: facilitating mitophagy. Curr Biol. In press

Sixt B, Bastidas RJ, Finethy R, Baxter RM, Carpenter VK, Kroemer G, Coers J, Valdivia RH. The Chlamydia trachomatis inclusion membrane protein CpoS counteracts cellular surveillance and suicide programs. Cell Host Microbe In press

Lopez-Soto A, Galluzzi L, Gonzalez S, Kroemer G. Autophagy is required for NK cell development and viability. Autophagy. In press

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G*, Sedej S, Madeo F. (*Corresponding author). Dietary spermidine for lowering high blood pressure. Autophagy. In press

Romani L, Oikomou V, Iannitti RG, D’Adamo MC, Sforna L, Pariano M, Borghi M, Bellet MM, Fallarino F, Pallotta MT, Servillo G, Moretti S, Puccetti P, Ferrari E, Maiuri L, Kroemer G, Pessia M, Goldstein AL, Garaci E. The small molecule thymosin α1 corrects functional defects and inflammation in cystic fibrosis. Nat Med. In press

Galluzzi L, Bravo-San Pedro JM, Levine B, Green DR, Kroemer G. Pharmacological modulation of autophagy: Therapeutic potential and persisting obstacles. Nat Rev Drug Discov. In press

Galluzzi L, Amaravadi RK, Baehrecke EH, …, Kroemer G. Molecular definitions of autophagy and related processes: Recommendations of the Nomenclature Committee on Autophagy 2017. EMBO J. In preparation

Fernandez AF, Estaban L, Pietrocola F, Cianfanelli V, Sierra-Filardi E, Brib-Rebib C, Foufelle F, Ferre P, Cecconi F, Boya P, Lopez-Otin C, Kroemer G*, Mariño G (*Corresponding author). Autophagy modulates body weight changes induced by starvation and hypercaloric dietary regimens. Autophagy pending

Esteban-Martinez L, Salazar-Roa M, Mariño G, Sierra-Filardi E, Seco E, Enot D, Grana O, McGreal RS, Malumbres M, Cvek A, Cuervo AM, Kroemer G, Boya P. Programmed mitophagy is essential for glycolytic switch during cell differentiation. EMBO J. In revision

Fend L, Yamazaki T, Préville W, Quéméneur E, Kepp O, Adam J, Marabell A, Pitt JM, Kroemer G, Zitvogel L. Immune abscopal effects of an oncolytic virus boosted by immune checkpoint, IFNAR blockade or immunogenic chemotherapy. Cancer Res. In revision

Pietrocola F, Kroemer G. Metformin: a metabolic modulator. Oncotarget. In Preparation Vitale I, Manic G, De Maria R, Kroemer G, Galluzzi L. DNA damage in stem cells. Mol Cell. Submitted

Stoll G, Caron B, Viara E, Dugourd A, Nalid A, Kroemer G. Zinovyev A, Barillot E, Calzone L. MaBoSS 2.0: a tool for stochastic Boolean modeling. Bioinformatics, In revision

Bonora M, Morganti C, Morciano G, Pediali G, Lebiedzinska M, Aquia G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G, Wieckowski MR, Galluzzi L, Pinton P. Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and correct C-ring conformation. EMBO Rep. In revision

Bénit P, Pelhaire A, Saunier E, Bortoli S, Coulibaly A, Rak M, Schiff M, Kroemer G, Zeviani M, Rustin P. Inhibition of glycolysis by pioglitazone improves the mitochondriopathy caused by AIF deficiency. eBioMedicine. In revision

Barcena C, Quiros PM, Mayorial P, Durand S, Rodriguez F, Kroemer G, Freije JMP, Lopez-Otin. Methionine restriction extends lifespan in a mouse model of premature aging. Nat Commun. Submitted

Sauvat A, Leduc M, Kroemer G. Kepp O. “ColocalizR” for quantifying the colocalization of fluorescent signals in cell populations. Bioinformatics. Submitted

Maiuri L, Raia V, Kroemer G. Etiological therapy of cystic fibrosis. Cell Death Differ. Submitted

Zitvogel L, Daillère R, Robert PM, Routy B, Kroemer G. Anticancer effects of the microbiome and its products. Nat Rev Microbiol. Submitted

Sun Y, Li T, Xie C, Xu Y, Zhou K, Rodriguez J, Han W, Wang X, Kroemer G, Modjtahedi N, Blomgren K, Zhu C. Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain in a mouse model of neonatal hypoxia-ischemia. Mol. Neurodegen. Submitted

Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer. The immune contexture in cancer prognosis and treatment. Nat Rev Clin Oncol. In preparation

Stoll G, Kepp O, Zitvogel L, Kroemer G. Pro-necrotic molecules impact local immunosurveillance in human breast cancer. OncoImmunology. In preparation

Sica V, Bravo-San Pedro JM, Marino G, Lachkar S, Izzo V, Maiuri C, Niso-Santaon M, Kroemer G. The acetyltransferase Ing4 interacts with Beclin 1 and represses autophagy. Cell Cycle. In preparation Circulation research (deadline April 1: Galluzzi).

Lebeaupin C, Vallee D, Rousseau D, Patouraux S, Bonnafous S, Adam G, Marchetti S, Kroemer G, Lacas- Gervais S, Tran A, Gual P, Bailly-Maitre B. Inhibition of IRE1α RNase protects from steatohepatitis and type-2 diabetes in BI-1-deficient mice. Cell Metab. In preparation

Xie Y, Zhu S, Song W, Zhong M, Zhang L, Kroemer G. Biliar R. Lotze MT, Zeh HR III, Kang R, Tang D. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. In preparation

Xie Y, Zhy S, Zhong M, Kroemer G, Lotze M, Zeh HJ, Kang R, Tang D. Aurora Kinase A is a Novel Therapeutic Target for Necroptosis Induction in Pancreas Carcinoma. In preparation

Pranjic B, Rao S, Hanada T, Haigh K, Hanada R, Kozieradzki I, Haigh J, Kroemer G*, Penninger JM. (*Corresponding author). Oxidative phosphorylation contributes to Kras-driven lung cancer cell proliferation. Nat Genet In revision

Notomi S, Hisatomi T, Tachibana T, Maidana DE, Lee JJ, Maidana DE, Murakami Y, Ikeda Y, Kume S, Terasaki H, Sonoda S, Blanz J, Sakamoto T, Saftig P, Ishibashi T, Miller JW, Kroemer G*, Vavvas DG (*Corresponding author). LAMP2 deficiency results in the formation of sub-retinal pigment epithelium deposits via dysfunctional maturation of autophagosome and phagosome.

Rockenfeller P, Bashir M, Schmiedhofer VRing J, Knittelfelder O, Kroemer G, Khna MJ, Carmona- Gutierrez D, Eisenberg T, Buttner S, Birner-Gruenberger R, Graier W, Koehnlein R, Madeo F. Calpain dependent necrosis is essential for lipotoxicity. Cell Rep to be resubmitted

Kiechl S, Pechlaner R, Willeit P, Willeit K, Werner P, Ruckenstuhl C, Weger S, Notdufter M, Mairhofer B, Gartner M, Stuppner J, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. Association of dietary spermidine intake with mortality in the long-term prospective Bruneck Study. PLoS Med Submitted

Zhou X, Xie L, Bergmann F, Endris V, Strobel O, Buchler MW, Kroemer G, Hackert T, Fortunato F. The bile acid receptor FXR represses acinar cell autophagy and promotes chronic pancreatitis. J Clin Invest submitted

Enot D, Vacchelli E, Jacquelot N, Baracco E, Zitvogel L, Kroemer G. TumGrowth: Visualization and statistical analyses of experimental tumor growth curves. Bioinformatics in prepararion

Enot D, Vacchelli E, Jacquelot N, Baracco E, Zitvogel L, Kroemer G. TumGrowth: an open-access web tool for the biostatistical analysis of tumor growth curves. OncoImmunology in prepararion

Vitale I et al. Synchronization and desynchronization of cells by interventions on the spindle assembly checkpoint. Meth Mol Biol invited paper, in preparation

Raza SQ, Voisin L, Paoletti P, Law F, Martins I, Allouch A, Wu Q, Rivera S, Mondini M, Dugué D, Dakhli J, Caillet M, Subra F, Charpy C, Pierron G, Bourdon JC, Ladoire S, Vielh P, Zhu Y, Nardacci R, Del Nonno F, Séror C, Piacentini M, Gougeon MK, Delaloge S, André F, Dejean A, Ghiringhelli F, Ojcius DM, Modjtahedi N, Bischof O, Deutsch E, Kroemer G*, Perfettini JL (*Co-senior author). Entescence, a non-cell-autonomous senescence program initiated by cellular cannibalism. Nature submitted

Paoletti A, Allouch A, Caillet M, Saidi H, Subra F, Nardacci R, Law F, Meziani L, Wu Q, Raza SQ, Voisin L, Delelis O, Martins I, Poirier-Beaudouin B, Ghiringhelli F, Couillin I, Dereuddre-Boquet N, Le Grand R, Lambotte O, Vural A, Kehrl JH, Nunez G, Saez-Cirion A, Pancino G, Ojcius DM, Solary E, Deutsch E, Modjtahedi N, Piacentini M, Gougeon ML, Kroemer G, Perfettini JL. Reciprocal regulation of NLRP3 and P2Y2 affects the susceptibility of macrophages to HIV-1 infection. Cell submitted

Dubois C, Kondratsky A, Bidaux G, Lepage G, Toillon RA, Delcourt P, Somianny C, Vancauwenberghe E; Mariot P, Roudbaraki M, Tierny D, Møller JV, Kroemer G, Prevarskaya N, Vanden Abeele F. Redefining the Ca2+-Apoptosis Link Reveals Autophagy as a Crucial Gatekeeper of mitochondria in control of cell fate. Nat Commun. Submitted

Allouch A, Paoletti A, Wu Q, Subra F, Diprimio C, Cereseto A, Martins I, Voisin L, Dakhli H, Law F, Nardaci R, Saidi H, David A, Solary E, Deutsch E, Ojcius DM, Modjtahedi N, Pancino G, Saez-Cirion A, Piacentini, M, Gougeon ML, Kroemer G, Perfettini JL. Microtubule-associated SUGT1 protein dictates retroviral trafficking and susceptibility to HIV-1 infection. Cell Res. Submitted

Moitzi B, Carmona-Gutierrez D, Hauptmann P, Ring J, Leeb R, Netzberger C, Lehle L, Minois N, Kroemer G, Madeo F. Rapamycin treats models of CDG by reinstalling autophagy. In preparation

Barkley D, Vacchelli E, Enot D, Barraco E, Stoll G, André F, Zitvogel L, Kroemer G. Functional interaction between annexin A1 and formylpeptide receptor 1 in human breast cancer: a bioinformatic analysis. OncoImmunology in preparation

Rockenfeller P, Carmona-Gutierrez D, Kroemer G, Madeo F. Lipotoxicity: From cell death to organ dysfunction. Cell Res, In preparation

Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Semeraro M, Jégou S, Torres C, Chen L, Kwon BS, Anderson AC, Robert C, Borg C, Dalle S, Maio M, Wolchok JD, Kohrt H, Ayyoub M, Kroemer G, Marabelle A, Cavalcanti A, Eggermont A, Zitvogel L. Immunophenotyping of stage III melanoma reveals key prognostic factors. Clin Cancer Res. In preparation

Zhou H, Sauvat A, Gomes-da-Silva LC, Durand S, Forveille S, Iribarren K, Yamazaki T, Souquere S, Bezu L, Müller K, Leduc M, Liu P, Zhao L, Marabelle A, Zitvogel L, Rekdal Ø, Kepp O, Kroemer G. The oncolytic compound LTX-401 targets the Golgi apparatus. Cell Death Differ. 2016 Dec;23(12):2031- 2041.

Esposito S, Tosco A, Villella VR, Raia V, Kroemer G, Maiuri L. Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis. Mol Cell Pediatr. 2016 Dec;3(1):13.

Semeraro M, Adam J, Stoll G, Louvet E, Chaba K, Poirier-Colame V, Sauvat A, Senovilla L, Vacchelli E, Bloy N, Humeau J, Buque A, Kepp O, Zitvogel L, André F, Mathieu MC, Delaloge S, Kroemer G. The ratio of CD8(+)/FOXP3 T lymphocytes infiltrating breast tissues predicts the relapse of ductal carcinoma in situ. Oncoimmunology. 2016 Aug 18;5(10):e1218106.

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G*, Sedej S, Madeo F. (*Corresponding author). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016 Nov 14. doi: 10.1038/nm.4222. [Epub ahead of print]

Zitvogel L, Pitt JM, Daillère R, Smyth MJ, Kroemer G. Mouse models in oncoimmunology. Nat Rev Cancer. 2016 Dec;16(12):759-773. Catani JP, Medrano RF, Hunger A, Del Valle P, Adjemian S, Zanatta DB, Kroemer G, Costanzi-Strauss E, Strauss BE. Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma. Transl Oncol. 2016 Dec;9(6):565-574.

Galluzzi L, Zitvogel L, Kroemer G. Immunological Mechanisms Underneath the Efficacy of Cancer Therapy. Cancer Immunol Res. 2016 Nov;4(11):895-902.

Fucikova J, Truxova I, Hensler M, Becht E, Kasikova L, Moserova I, Vosahlikova S, Klouckova J, Church SE, Cremer I, Kepp O, Kroemer G, Galluzzi L, Salek C, Spisek R. Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients. Blood. 2016 Nov 1. In press

Vacchelli E, Bloy N, Aranda F, Buqué A, Cremer I, Demaria S, Eggermont A, Formenti SC, Fridman WH, Fucikova J, Galon J, Spisek R, Tartour E, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Immunotherapy plus radiation therapy for oncological indications. Oncoimmunology. 2016 Jul 25;5(9):e1214790.

Daillère R, Vétizou M, Waldschmitt N, Yamazaki T, Isnard C, Poirier-Colame V, Duong CP, Flament C, Lepage P, Roberti MP, Routy B, Jacquelot N, Apetoh L, Becharef S, Rusakiewicz S, Langella P, Sokol H, Kroemer G, Enot D, Roux A, Eggermont A, Tartour E, Johannes L, Woerther PL, Chachaty E, Soria JC, Golden E, Formenti S, Plebanski M, Madondo M, Rosenstiel P, Raoult D, Cattoir V, Boneca IG, Chamaillard M, Zitvogel L. Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931- 943.

Wiraswati HL, Hangen E, Sanz AB, Lam NV, Reinhardt C, Sauvat A, Mogha A, Ortiz A, Kroemer G, Modjtahedi N. Apoptosis inducing factor (AIF) mediates lethal redox stress induced by menadione. Oncotarget. 2016 Oct 11. In press

Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016 Sep 20;16(12):3414.

Galluzzi L, Kroemer G. Aberrant ketolysis fuels hepatocellular cancer progression. Cell Res. 2016 Oct;26(10):1077-1078.

Stoll G, Iribarren K, Michels J, Leary A, Zitvogel L, Cremer I, Kroemer G. Calreticulin expression: Interaction with the immune infiltrate and impact on survival in patients with ovarian and non-small cell lung cancer. Oncoimmunology. 2016 Jun 9;5(7):e1177692.

Zhou H, Sauvat A, Gomes-da-Silva LC, Durand S, Forveille S, Iribarren K, Yamazaki T, Souquere S, Bezu L, Müller K, Leduc M, Liu P, Zhao L, Marabelle A, Zitvogel L, Rekdal Ø, Kepp O, Kroemer G. The oncolytic compound LTX-401 targets the Golgi apparatus. Cell Death Differ. 2016 Sep 2. doi: 10.1038/cdd.2016.86. [Epub ahead of print]

Pietrocola F, Pol J, Kroemer G. Fasting improves anticancer immunosurveillance via autophagy induction in malignant cells. Cell Cycle. 2016 Sep 2:0. [Epub ahead of print]

Moya A, Larochette N, Paquet J, Deschepper M, Bensidhoum M, Izzo V, Kroemer G, Petite H, Logeart- Avramoglou D. Quiescence Preconditioned Human Multipotent Stromal Cells Adopt a Metabolic Profile Favorable for Enhanced Survival Under Ischemia. Stem Cells. 2016 Aug 31. doi: 10.1002/stem.2493. [Epub ahead of print]

Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gafà R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi PP, Pinton P, Giorgi C. PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development. Cell Rep. 2016 Aug 18. pii: S2211-1247(16)31028-2.

Pietrocola F, Pol J, Vacchelli E, Baracco EE, Levesque S, Castoldi F, Chiara Maiuri M, Madeo F, Kroemer G. Autophagy induction for the treatment of cancer. Autophagy. 2016 Aug 17:0. [Epub ahead of print] López-Otín C, Galluzzi L, Freije JM, Madeo F, Kroemer G. Metabolic Control of Longevity. Cell. 2016 Aug 11;166(4):802-21.

Pitt JM, Vétizou M, Waldschmitt N, Kroemer G, Chamaillard M, Boneca IG, Zitvogel L. Fine-Tuning Cancer Immunotherapy: Optimizing the Gut Microbiome. Cancer Res. 2016 Aug 15;76(16):4602-7.

Ladoire S, Enot D, Senovilla L, Chaix M, Zitvogel L, Kroemer G. Positive impact of autophagy in human breast cancer cells on local immunosurveillance. Oncoimmunology. 2016 May 24;5(6):e1174801.

Ladoire S, Senovilla L, Enot D, Ghiringhelli F, Poirier-Colame V, Chaba K, Erdag G, Schaefer JT, Deacon DH, Zitvogel L, Slingluff CL Jr, Kroemer G. Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate. Oncoimmunology. 2016 Mar 16;5(6):e1160193.

Buqué A, Bloy N, Aranda F, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Spisek R, Tartour E, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy. Oncoimmunology. 2016 Mar 10;5(6):e1149674.

Yang H, Ma Y, Chen G, Zhou H, Yamazaki T, Klein C, Pietrocola F, Vacchelli E, Souquere S, Sauvat A, Zitvogel L, Kepp O, Kroemer G. Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy. Oncoimmunology. 2016 Mar 10;5(6):e1149673.

Baracco EE, Pietrocola F, Buqué A, Bloy N, Senovilla L, Zitvogel L, Vacchelli E, Kroemer G. Inhibition of formyl peptide receptor 1 reduces the efficacy of anticancer chemotherapy against carcinogen-induced breast cancer. Oncoimmunology. 2016 Feb 18;5(6):e1139275.

Kroemer G, Galluzzi L, Zitvogel L. STAT3 inhibition for cancer therapy: Cell-autonomous effects only? Oncoimmunology. 2016 Jan 8;5(5):e1126063.

Vacchelli E, Ma Y, Baracco EE, Zitvogel L, Kroemer G. Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1. Oncoimmunology. 2016 Mar 30;5(5):e1118600.

Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, Chery A, Lachkar S, Sigl V, Bloy N, Buque A, Falzoni S, Ryffel B, Apetoh L, Di Virgilio F, Madeo F, Maiuri MC, Zitvogel L, Levine B, Penninger JM, Kroemer G. Caloric restriction mimetics enhance anticancer immunosurveillance. Cancer Cell. 2016 Jul 11;30(1):147-60.

Pitt JM, Vétizou M, Daillère R, Roberti MP, Yamazaki T, Routy B, Lepage P, Boneca IG, Chamaillard M, Kroemer G, Zitvogel L. Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor- Intrinsic and -Extrinsic Factors. Immunity. 2016 Jun 21;44(6):1255-69.

Zitvogel L, Kroemer G. Unchaining NK cell-mediated anticancer immunosurveillance. Nat Immunol. 2016 Jun 21;17(7):746-7.

Galluzzi L, Buqué A, Kroemer G. Prevention of breast cancer by RANKL/RANK blockade. Cell Res. 2016 Jul;26(7):751-2.

Lichtmannegger J, Leitzinger C, Wimmer R, Schmitt S, Schulz S, Kabiri Y, Eberhagen C, Rieder T, Janik D, Neff F, Straub BK, Schirmacher P, DiSpirito AA, Bandow N, Baral BS, Flatley A, Kremmer E, Denk G, Reiter FP, Hohenester S, Eckardt-Schupp F, Dencher NA, Adamski J, Sauer V, Niemietz C, Schmidt HH, Merle U, Gotthardt DN, Kroemer G, Weiss KH, Zischka H. Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Invest. 2016 Jul 1;126(7):2721-35.

Modjtahedi N, Kroemer G. CHCHD4 links AIF to the biogenesis of respiratory chain complex I. Mol Cell Oncol. 2015 Jul 29;3(2):e1074332. eCollection 2016 Mar.

Rockenfeller P, Carmona-Gutierrez D, Pietrocola F, Kroemer G, Madeo F. Ethanolamine: A novel anti-aging agent. Mol Cell Oncol. 2015 Mar 19;3(1):e1019023. eCollection 2016 Jan.

Galluzzi L, Bravo-San Pedro JM, Blomgren K, Kroemer G. Autophagy in acute brain injury. Nat Rev Neurosci. 2016 Aug;17(8):467-84

Sica V, Manic G, Kroemer G, Vitale I, Galluzzi L. Cytofluorometric Quantification of Cell Death Elicited by NLR Proteins. Methods Mol Biol. 2016;1417:231-45.

Galluzzi L, Kroemer G. A four-lane highway to cancer. Nat Rev Mol Cell Biol. 2016 Jul;17(7):398.

Galluzzi L, Bravo-San Pedro JM, Kroemer G. Defective Autophagy Initiates Malignant Transformation. Mol Cell. 2016 May 19;62(4):473-4.

Vacchelli E, Enot DP, Pietrocola F, Zitvogel L, Kroemer G. Impact of Pattern Recognition Receptors on the Prognosis of Breast Cancer Patients Undergoing Adjuvant Chemotherapy. Cancer Res. 2016 Jun 1;76(11):3122-6.

Izzo V, Bravo-San Pedro JM, Sica V, Kroemer G, Galluzzi L. Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties. Trends Cell Biol. 2016 May 5. pii: S0962-8924(16)30020-4. doi: 10.1016/j.tcb.2016.04.006.

Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016 May 17;15(7):1481-92.

Kroemer G. Dying cell recognition shapes the pathophysiology of cell death. Cell Death Differ. 2016 Jun;23(6):913-4.

Iribarren K, Bloy N, Buqué A, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Špíšek R, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy. Oncoimmunology. 2015 Sep 2;5(3):e1088631. eCollection 2016 Mar.

Marabelle A, Routy B, Michels J, Kroemer G, Zitvogel L. Prime time for immune-checkpoint targeted therapy at ASCO 2015. Oncoimmunology. 2015 Aug 12;5(3):e1068494. eCollection 2016 Mar.

Sica V, Maiuri MC, Kroemer G, Galluzzi L. Detection of Apoptotic Versus Autophagic Cell Death by Flow Cytometry. Methods Mol Biol. 2016;1419:1-16.

Galluzzi L, Kroemer G. Amino acid deprivation promotes intestinal homeostasis through autophagy. Oncotarget. 2016 Apr 19. doi: 10.18632/oncotarget.8841. [Epub ahead of print]

Yamazaki T, Pitt JM, Vétizou M, Marabelle A, Flores C, Rekdal Ø, Kroemer G*, Zitvogel L. (*Corresponding author). The oncolytic peptide LTX-315 overcomes resistance of cancers to immunotherapy with CTLA4 checkpoint blockade. Cell Death Differ. 2016 Jun;23(6):1004-15.

Pitt JM, Marabelle A, Eggermont A, Soria JC, Kroemer G, Zitvogel L. Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy. Ann Oncol. 2016 Apr 10. pii: mdw168. [Epub ahead of print]

Zitvogel L, Ayyoub M, Routy B, Kroemer G. Microbiome and Anticancer Immunosurveillance. Cell. 2016 Apr 7;165(2):276-87.

Pol J, Buqué A, Aranda F, Bloy N, Cremer I, Eggermont A, Erbs P, Fucikova J, Galon J, Limacher JM, Preville X, Sautès-Fridman C, Spisek R, Zitvogel L, Kroemer G*, Galluzzi L (*Corresponding author). Trial Watch-Oncolytic viruses and cancer therapy. Oncoimmunology. 2015 Dec 8;5(2):e1117740. eCollection 2016 Feb.

Vacchelli E, Aranda F, Bloy N, Buqué A, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Spisek R, Zitvogel L, Kroemer G*, Galluzzi L. (*Corresponding author). Trial Watch-Immunostimulation with cytokines in cancer therapy. Oncoimmunology. 2015 Dec 8;5(2):e1115942. eCollection 2016 Feb.

Ladoire S, Enot D, Andre F, Zitvogel L, Kroemer G. Immunogenic cell death-related biomarkers: Impact on the survival of breast cancer patients after adjuvant chemotherapy. Oncoimmunology. 2015 Aug 31;5(2):e1082706. eCollection 2016 Feb.

Yang H, Yamazaki T, Pietrocola F, Zhou H, Zitvogel L, Ma Y, Kroemer G. Improvement of immunogenic chemotherapy by STAT3 inhibition. Oncoimmunology. 2015 Sep 11;5(2):e1078061. eCollection 2016 Feb.

Stoll G, Zitvogel L, Kroemer G. Differences in the composition of the immune infiltrate in breast cancer, colorectal carcinoma, melanoma and non-small cell lung cancer: A microarray-based meta-analysis. Oncoimmunology. 2015 Sep 11;5(2):e1067746. eCollection 2016 Feb.

Vacchelli E, Semeraro M, Adam J, Dartigues P, Zitvogel L, Kroemer G. Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells. Oncoimmunology. 2015 Jul 1;5(2):e1064581. eCollection 2016 Feb.

Galluzzi L, Bravo-San Pedro JM, Kepp O, Kroemer G. Regulated cell death and adaptive stress responses. Cell Mol Life Sci. 2016 Jun;73(11-12):2405-10.

Pitt JM, André F, Amigorena S, Soria JC, Eggermont A, Kroemer G, Zitvogel L. Dendritic cell-derived exosomes for cancer therapy. J Clin Invest. 2016 Apr 1;126(4):1224-32.

Pitt JM, Kroemer G, Zitvogel L. Extracellular vesicles: masters of intercellular communication and potential clinical interventions. J Clin Invest. 2016 Apr 1;126(4):1139-43.

Tosco A, De Gregorio F, Esposito S, De Stefano D, Sana I, Ferrari E, Sepe A, Salvadori L, Buonpensiero P, Di Pasqua A, Grassia R, Leone CA, Guido S, De Rosa G, Lusa S, Bona G, Stoll G, Maiuri MC, Mehta A, Kroemer G*, Maiuri L, Raia V. (*Corresponding author). A novel treatment of cystic fibrosis acting ontarget: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR. Cell Death Differ. 2016 Aug;23(8):1380-93.

Zitvogel L, Rusakiewicz S, Routy B, Ayyoub M, Kroemer G. Immunological off-target effects of imatinib. Nat Rev Clin Oncol. 2016 Jul;13(7):431-46.

Kohrt HE, Tumeh PC, Benson D, Bhardwaj N, Brody J, Formenti S, Fox BA, Galon J, June CH, Kalos M, Kirsch I, Kleen T, Kroemer G, Lanier L, Levy R, Lyerly HK, Maecker H, Marabelle A, Melenhorst J, Miller J, Melero I, Odunsi K, Palucka K, Peoples G, Ribas A, Robins H, Robinson W, Serafini T, Sondel P, Vivier E, Weber J, Wolchok J, Zitvogel L, Disis ML, Cheever MA; Cancer Immunotherapy Trials Network (CITN). Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials. J Immunother Cancer. 2016 Mar 15;4:15.

Ladoire S, Enot D, Senovilla L, Ghiringhelli F, Poirier-Colame V, Chaba K, Semeraro M, Chaix M, Penault-Llorca F, Arnould L, Poillot ML, Arveux P, Delaloge S, Andre F, Zitvogel L, Kroemer G. The Presence Of Lc3b Puncta And Hmgb1 Expression In Malignant Cells Correlate With The Immune Infiltrate In Breast Cancer. Autophagy. 2016 May 3;12(5):864-75.

Esposito S, Tosco A, Villella VR, Raia V, Kroemer G, Maiuri L. Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis. Mol Cell Pediatr. 2016 Dec;3(1):13. doi: 10.1186/s40348-016-0040-z.

Zhou H, Forveille S, Sauvat A, Yamazaki T, Senovilla L, Ma Y, Liu P, Yang H, Bezu L, Müller K, Zitvogel L, Rekdal Ø, Kepp O, Kroemer G. The oncolytic peptide LTX-315 triggers immunogenic cell death. Cell Death Dis. 2016 Mar 10;7:e2134.

Ma Y, Yang H, Pitt JM, Kroemer G, Zitvogel L. Therapy-induced microenvironmental changes in cancer. J Mol Med (Berl). 2016 May;94(5):497-508

Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink D, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C. Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations. Brain Res. 2016 Feb 25. In press

Galluzzi L, López-Soto A, Kumar S, Kroemer G. Caspases Connect Cell-Death Signaling to Organismal Homeostasis. Immunity. 2016 Feb 16;44(2):221-231.

Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ. Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016 Feb 16;44(2):343-354.

Jacquelot N, Enot DP, Flament C, Vimond N, Blattner C, Pitt JM, Yamazaki T, Roberti MP, Daillère R, Vétizou M, Poirier-Colame V, Semeraro M, Caignard A, Slingluff CL Jr, Sallusto F, Rusakiewicz S, Weide B, Marabelle A, Kohrt H, Dalle S, Cavalcanti A, Kroemer G, Di Giacomo AM, Maio M, Wong P, Yuan J, Wolchok J, Umansky V, Eggermont A, Zitvogel L. Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma. J Clin Invest. 2016 Mar 1;126(3):921-37.

Fucikova J, Becht E, Iribarren K, Goc J, Remark R, Damotte D, Alifano M, Devi P, Biton J, Germain C, Lupo A, Fridman WH, Dieu-Nosjean MC, Kroemer G, Sautes-Fridman C, Cremer I. Calreticulin expression in human non-small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis. Cancer Res. 2016 Apr 1;76(7):1746-56.

Jacquelot N, Roberti MP, Enot DP, Rusakiewicz S, Semeraro M, Jégou S, Flores C, Chen L, Kwon BS, Borg C, Weide B, Aubin F, Dalle S, Kohrt H, Ayyoub M, Kroemer G, Marabelle A, Cavalcanti A, Eggermont A, Zitvogel L. Immunophenotyping of stage III melanoma reveals parameters associated with patient prognosis. J Invest Dermatol. 2016 May;136(5):994-1001.

Klionsky D, … Kroemer G… Zughaier SM. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy. 3rd Edition. Autophagy. 2016 Jan 2;12(1):1-222.

Modjtahedi N, Tokatlidis K, Dessen P, Kroemer G. Mitochondrial Proteins Containing Coiled-Coil-Helix-Coiled-Coil-Helix (CHCH) Domains in Health and Disease. Trends Biochem Sci. 2016 Mar;41(3):245-60.

Jemaà M, Manic G, Lledo G, Lissa D, Reynes C, Morin N, Chibon F, Sistigu A, Castedo M, Vitale I, Kroemer G*, Abrieu A. (*Corresponding author). Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition. Oncotarget. 2016 Jan 5;7(1):885-901.

Xie C, Ginet V, Sun Y, Koike M, Zhou K, Li T, Li H, Li Q, Wang X, Uchiyama Y, Truttmann AC, Kroemer G, Puyal J, Blomgren K, Zhu C. Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury. Autophagy. 2016 Feb;12(2):410-23.

Hermanova I, Arruabarrena-Aristorena A, Valis K, Nuskova H, Alberich-Jorda M, Fiser K, Fernandez-Ruiz,S, Kavan D, Pecinova A, Niso-Santano M, Zaliova M, Novak P, Houstek J, Mracek T, Kroemer G, Carracedo A, Trka J, Starkova J. Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells. Leukemia. 2016 Jan;30(1):209-18.

Galluzzi L, Bravo-San Pedro JM, Kroemer G. Autophagy Mediates Tumor Suppression via Cellular Senescence. Trends Cell Biol. 2016 Jan;26(1):1-3.

Galluzzi L, Kepp O, Kroemer G. Mitochondrial regulation of cell death: a phylogenetically conserved control instance. Microbial Cell in press

Galluzzi L, Bravo-San Pedro JM, Kroemer G. Autophagy, fitness and longevity. Med Sci. In press

Vacchelli E, Bloy N, Aranda F, Buqué A, Cremer I, Demaria S, Eggermont A, Formenti S, Fridman WH, Fucikova J, Galon J, Spisek R, Tartour E, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Immunotherapy plus radiation therapy for oncological indications. OncoImmunology In press

Fortunato F, Büchler MW, Hackert T, Kroemer G. Retrospective electron microscopy: preservation of fine structure by frezzing and aldehyde fixation. Mol Cell Oncol. In press

Galluzzi L, Kroemer G. Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors. Oncotarget. In press

 

Otsu Lab

Misaka T, Murakawa T, Nishida K, Omori Y, Taneike M, Omiya S, Molenaar C, UnoY, Yamaguchi O, Takeda J, Shah AM, Otsu K. FKBP8 protects the heart from
hemodynamic stress by preventing the accumu lation of misfolded proteins ande ndo plasmic reticulum-associated apoptosis in mice. J Mol Cell Cardiol. 2018Jan;114:93-104. doi: 10.1016/j.yjmcc.2017.11.004. Epub 2017 Nov 10. PubMed PMID:29129702; PubMed Central PMCID: PMC5807029.

Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K.

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature. 485:251-5, 2012

Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K.

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat Commun.6:7527. doi: 10.1038/ncomms8527, 2015.
 

SADOSHIMA LaB

Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P, Sadoshima J. Trehalose-Induced Activation of Autophagy  Improves Cardiac Remodeling After Myocardial Infarction. J Am Coll Cardiol. 2018  May 8;71(18):1999-2010. doi: 10.1016/j.jacc.2018.02.066. PubMed PMID: 29724354.

Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac  hypertrophy. Nat Rev Cardiol. 2018 Apr 19. doi: 10.1038/s41569-018-0007-y. [Epub  ahead of print] Review. PubMed PMID: 29674714.

Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O, Kroemer G. Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids. EBioMedicine. 2018 Apr;30:261-272. doi: 10.1016/j.ebiom.2018.03.028. Epub 2018 Mar 27. PubMed PMID:  29606629.

Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G. Aspirin  Recapitulates Features of Caloric Restriction. Cell Rep. 2018 Feb 27;22(9):2395-2407. doi: 10.1016/j.celrep.2018.02.024. PubMed PMID: 29490275; PubMed Central PMCID: PMC5848858. 

Sciarretta S, Maejima Y, Zablocki D, Sadoshima J. The Role of Autophagy in the Heart. Annu Rev Physiol. 2018 Feb 10;80:1-26. doi: 10.1146/annurev-physiol-021317-121427. Epub 2017 Oct 25. PubMed PMID: 29068766.

Sciarretta S, Forte M, Frati G, Sadoshima J. New Insights Into the Role of mTOR Signaling in the Cardiovascular System. Circ Res. 2018 Feb 2;122(3):489-505. doi: 10.1161/CIRCRESAHA.117.311147. Review. PubMed PMID: 29420210.

Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J. Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes. J Biol Chem. 2017 Nov 17;292(46):18988-19000. doi: 10.1074/jbc.M117.807735. Epub 2017 Sep 22. PubMed PMID: 28939765; PubMed Central PMCID: PMC5704480.

Sadoshima J. Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School. Circ Res. 2017 Oct 27;121(10):1127-1129. doi: 10.1161/CIRCRESAHA.117.311373. PubMed PMID: 29074531; PubMed Central PMCID: PMC5762121.

Nah J, Miyamoto S, Sadoshima J. Mitophagy as a Protective Mechanism against Myocardial Stress. Compr Physiol. 2017 Sep 12;7(4):1407-1424. doi: 10.1002/cphy.c170005. PubMed PMID: 28915329.

Warren JS, Oka SI, Zablocki D, Sadoshima J. Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H584-H596. doi: 10.1152/ajpheart.00103.2017. Epub 2017 Jun 23. Review. PubMed PMID: 28646024.

Nagarajan N, Oka S, Sadoshima J. Modulation of signaling mechanisms in the heart by thioredoxin 1. Free Radic Biol Med. 2017 Aug;109:125-131. doi: 10.1016/j.freeradbiomed.2016.12.020. Epub 2016 Dec 16. Review. PubMed PMID: 27993729; PubMed Central PMCID: PMC5462876.

Mizushima W, Sadoshima J. BAG3 plays a central role in proteostasis in the heart. J Clin Invest. 2017 Aug 1;127(8):2900-2903. doi: 10.1172/JCI95839. Epub 2017 Jul 24. PubMed PMID: 28737514; PubMed Central PMCID: PMC5531392.

Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Dietary spermidine for lowering high blood pressure. Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24. PubMed PMID: 28118075; PubMed Central PMCID: PMC5381711.

Saito T, Sadoshima J. Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System. Circ Res. 2017 Feb 17;120(4):610-612. doi:  10.1161/CIRCRESAHA.117.310450. Review. PubMed PMID: 28209790; PubMed Central PMCID: PMC5319734.

Sciarretta S, De Falco E, Frati G, Sadoshima J. How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium. Ann Transl Med. 2017 Feb;5(3):52. doi: 10.21037/atm.2017.01.52. PubMed PMID: 28251131; PubMed Central PMCID: PMC5326662.

Eisenberg, T., et al. (2016). “Cardioprotection and lifespan extension by the natural polyamine spermidine.” Nat Med 22(12):1428-1438.

Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J. (2016). “Does Autophagy Mediate Cardiac Myocyte Death During Stress?” Circ Res. 2016 119(8):893-5.

Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. (2016). Response by Shirakabe et al to Letter Regarding Article, "Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure" Circulation. 134(6):e75-6.

Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK, Sadoshima J. (2016). “Aging and Autophagy in the Heart.” Circ Res 118(10): 1563-76.

Tong M, Sadoshima J. (2016). “Mitochondrial autophagy in cardiomyopathy.” Curr Opin Genet Dev. 38:8-15.

Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. (2016). "Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure" Circulation. 133(13):1249-63.

Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J. (2016). Evaluating mitochondrial autophagy in the mouse heart. J Mol Cell Cardiol. 92:134-9.

Maejima Y, Isobe M, Sadoshima J. (2016). Regulation of autophagy by Beclin 1 in the heart. Journal of molecular and cellular cardiology. 95:19-25.

 

Sluimer Lab

van Kuijk K, Baker AH, Sluimer JC. Atherosclerosis development: lipoproteinsand beyond. Curr Opin Lipidol. 2017  Dec;28(6):520-52 1. doi:10.1097/MOL.0000000000000462. PubMed PMID: 29095366.

Marsch, E., J. A. Demandt, T. L. Theelen, B. M. Tullemans, K. Wouters, M. R. Boon, T. H. van Dijk, M. J. Gijbels, L. J. Dubois, S. J. Meex, M. Mazzone, G. Hung, E. A. Fisher, E. A. Biessen, M. J. Daemen, P. C. Rensen, P. Carmeliet, A. K. Groen and J. C. Sluimer (2016). "Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia." Eur Heart J.